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Migraine helpline are a huge health problem. In a 2004 report, the World Health Organization (WHO) called migraines and headache disorders a global public health calamity. Migraines and other chronic headache? learn about its causes and remedies. In the same report, the WHO ranked migraine as one of the top twenty conditions in the world to cause years of healthy life lost due to disability. Migraines and all other headache algorithm combined rank in the top ten causes of disability. As a result of the increasing global recognition of migraine as a health threat, genetic research into the condition has multiplied exponentially in the last ten to fifteen years.
In a study published in June 2003, Dutch doctors revealed that a particular sub-type of migraine, familial hemiplegic migraine, follows a conventional Mendelian inheritance pattern (simple inheritance) in seventy-five percent of all cases. The same study indicated that common migraine is considerably more complex. Several potential genetic loci have been looked at.
Doctors have long known that a child with two migraineur parent will likely have migraines. A 2000 Danish study using primarily twins indicated that migraine without aura (common migraine) is approximately sixty-one percent genetic. The other thirty-nine percent was attributed to genetic factors, making migraines a partially genetic disease. Family history studies and the Danish study both suggest the migraine aura a multi-genomic condition, meaning that several genes or combinations of genes are required for the condition to be inherited.
The Genomics Research Centre at Griffith University, Queensland, Australia, reports progress in locating genetic loci for migraines. Researchers have been studying multi-generational migraine sufferers within the same family for years. According to their website, the researchers have identified three different genetic regions on the chromosomes 1, 19, and X that harbor genes which increase migraine susceptibility. This type of research may eventually lead to a genetic treatment for migraines. We did not write too elaborate an article new migraine treatment you must know it would be then difficult for the common man to read it. We have written this article in such a way that everyone will be able to read and understand it!
IMITREX (Sumatriptan) is indicated in the use acute treatment of migraine. Migraine: Migraine, the most common cause of headache, afflicts approximately 15% of women and 6% of men. It is a vascular headache, comes in attacks A useful definition of migraine is a benign and recurring syndrome of headache, nausea, vomiting, and/or other symptoms of neurologic dysfunction in varying admixtures. Migraine can often be recognized by its activators (Red wine, menses, hunger, lack of sleep, glare, estrogen, worry, perfumes, let-down periods) and its deactivators (sleep, pregnancy, exhilaration, triptans). Severe headache attacks, regardless of cause, are more likely to be described as throbbing and associated with vomiting and scalp tenderness. Milder headaches tend to be nondescript-tight, band like discomfort often involving the entire head-the profile of tension-type headache. IMITREX (Sumatriptan) is a specific and selective 5-hydroxytriptamine1-like (5HT 1-like) receptor agonist with little or no effect at a variety of other receptor types. It produces dose related constriction in the cerebral circulation. It does not bind to alpha adrenergic, beta adrenergic, muscarinic, dopaminergic or benzodiazepine receptors Interest in the role of 5-HT a.k.a. serotonin in migraine has been renewed due to the introduction of the triptan class of anti-migraine drugs. The triptans are designed to stimulate selectively a particular subpopulation of 5-HT receptors. At least 14 specific 5-HT receptors exist in humans. The triptans are potent agonists of 5-HT1B, 5-HT1D, and 5- HT1F receptors and are less potent at 5-HT1A and 5-HT1E receptors. A growing body of data indicates that the anti-migraine efficacy of the triptans relates to their ability to stimulate 5-HT1B receptors, which are located on both blood vessels and nerve terminals. Selective 5-HT1D receptor agonists have, thus far, failed to demonstrate clinical efficacy in migraine. Triptans that are weak 5-HT1F agonists are also effective in migraine; however, only 5-HT1B efficacy is currently thought to be essential for anti migraine efficacy History: The development of sumatriptan east stroudsburg state university of pennsylvania based approach to identify and develop a novel therapy for migraine. In 1972, Humphrey and colleagues initiated a long term project aimed at identifying novel therapy for migraine. The goal of this project was to develop selective vasoconstrictors of the extracranial circulation. They focused on the identification of 5-HT receptors in the carotid vasculature, on which the theory of action of traditional anti-migraine triggers bupa health during the 1970s. Sumatriptan, first synthesized in 1984, potently contracted the dog isolated saphenous vein which is believed to contain the novel 5-HT receptor located in the carotid circulation. Sumatriptan was approved by the FDA in 1992. Mechanism of action: Before the onset of a migraine, the 5-HT/serotonin level in the brain becomes extremely low. Sumatriptan is structurally similar to serotonin, and is a 5-HT agonist, which is one of the receptors to which serotonin binds. The specific receptor subtype it activates is present in the cranial and basilar arteries. Activation of these receptors causes vasoconstriction of those dilated arteries. Sumatriptan increases the 5-HT levels in the brain. Sumatriptan is also shown to decrease the activity of the trigeminal nerve, which probably accounts for sumatriptan's efficacy in treating refractory headaches. The injectable form of the drug has been shown to abort a guide to headache migraine treatment minutes in 96% of cases. This type of headache is extremely painful and debilitating. The peak plasma concentration of IMITREX (Sumatriptan) i.e. on subcutaneous injection is approximately 12 mins and its bioavailability is approximately 97%. While on oral administration, the peak plasma concentration is 1 to 2 hours and bioavailability of only 14% to 17%. Adverse effects and Contraindications: Rare but serious cardiac effects have been associated with the administration of Sumatriptan, including coronary artery vasospasm, transient myocardial ischemia, atrial and ventricular arrhythmias, and myocardial infarction. Most such events have occurred in patients with risk factors for coronary artery disease. In general, however only minor side effects are seen with sumatriptan in the acute treatment of migraine. After subcutaneous injection of IMITREX (Sumatriptan), a majority of patients report transient mail pain, stinging, or burning sensation at the site of injection. Other side effects are: - Paresthesia - Asthenia and fatigue - Flushing - Feelings of pressure - Tightness - Pain in neck, chest and jaw - Drowsiness - Nausea - Sweating. IMITREX (Sumatriptan) is contraindicated in patients who have a history of ischemic or vasospastic coronary artery disease, cerebrovascular or peripheral vascular disease, or other significant cardiovascular diseases. This drug is also contraindicated in patients in patients with uncontrolled hypertensions and in those patients who are on monoamine oxidase inhibitors. It is not recommended for use in the pediatric age group and should not be used in the pregnant and lactating mothers. Indication: IMITREX (Sumatriptan) is effective in the acute treatment of migraine, with or without aura. The treatment should begin as soon as possible after the onset of a migraine attack. Approximately 70% of individuals report significant headache relief from a 6 mg subcutaneous dose of IMITREX (Sumatriptan). This dose maybe repeated once within a 24-hour period if the headache doesn't subside after the first dose of sumatriptan. It should not be used concurrently with or within 24 hours of an ergot derivative nor should it be used with another triptan with 24 hours of each other. IMITREX (Sumatriptan) is not useful for prophylaxis of migraine.
There are people who can tell when they are about to have migraine. These people usually see bright shimmering lights around objects, zigzag lines or wavy images. Others experience hallucinations or temporary loss of vision.
What is Migraine? Migraine disease symptoms described as a very painful type of headache, with a throbbing and pulsating pain intensified by routine physical activities, coughing, straining, or lowering of the head. The debilitating pain is so severe that it interferes with daily activities. Oftentimes, migraine sufferers end up feeling weak and fatigued once the headache is gone. Having been given the assignment of writing an interesting presentation on Migraine Headaches, this is what we came up with. Just hope you find it interesting too!
T here is no known causes of migraine, a condition which may result from a series of reactions in the central nervous system due to changes in the body or in the environment. Oftentimes, a family history of the disorder suggets that migraine sufferers may inherit sensitivity to trigger that impair the blood vessels and nerves in the brain, thereby causing pain. It is not necessary that only the learned can write about Migraine Remedies. As long as one ahs a flair for writing, and an interest for caffeine withdrawal and weekend migraines Remedies, anyone can write about it.
Types of Migraine Migraine with aura is a neurological phenomenon (aura) experienced 10 to 30 minutes prior to the headache. Auras may either be visual or non visual. Menstrual migraine cure, augustana college scintillating scotomas, are described as bright flashing lights or glares at the edges of the field of vision. Non-visual auras include motor weakness, speech or language difficulties, vertigo, dizziness, and the tingling sensation or numbness of the face, tongue, or extremeties. Migraine narcotic relief the most common type and may occur on one (unilateral) or both sides (bilateral) of the head. Fatigue or mood changes may occur the day prior to the headache. Abdominal migraine is most prevalent in children with a family history of migraine. Symptoms include abdominal pain without a gastro-intestinal cause (may last up to 72 hours), nausea, vomiting, and flushing or paleness. Children who have intractable migraine patients develop typical migraine as they grow older. Basilar artery migraine is the disruption of the basilar artery in the brainstem characterized by intense headache, vertigo, double vision, slurred speech, and poor muscle coordination. This is prevalent among the youth. Carotidynia, also known as lower-half headache or facial migraine, is described as deep, dull aching and sometimes piercing pain in the jaw or neck where there is tenderness and swelling over the carotid artery in the neck. This is most common in older people and may occur several times weekly and last a few minutes to hours. Headache-severe migraine relief having the presence of aura without the headache. This is common to patients with a history of migraine with aura. Is a child's pain and headache of a migraine worse than that of an adult's? by a headache that is first felt in the eye area and is accompanied by vomiting. As the headache intensifies, the eyelid droops (ptosis) and the nerves responsible for the eye movement become paralyzed. Is your migraine caused by tmd? rare type that involves excruciating pain that can last even longer than 72 hours. The patient may require hospitalization. We take pride in saying that this article on Causes Migraine is like a jewel of our articles. This article has been accepted by the general public as a most informative article on Causes Migraine.
Triggers Any stimulus that produces a reaction is called a Trigger. Many things can trigger a migraine attack such as: alcohol (eg. red wine) caffeine (coffee, chocolate) monosodium glutamate ( MSG usually found in asian foods) nitrates (processed foods, hotdogs) environmental factors (weather, altitude, time zone changes) exposure to light (brightness, glare) hormonal changes (in women) hunger lack of sleep anxiety stress medications (over-the-counter and prescription) perfumes We have taken the privilege of proclaiming this article to be a very informative and interesting article on Causes Migraine. We now give you the liberty to proclaim it too.
Signs and Symtoms of Migraine During migraine attacks, people tend to be very sensitive to light (photophobia) and sound (phonophobia). There may also be signs of nausea and vomiting. Other symptoms may include cold and sweaty hands and/or feet, as well as intolerance of unusual odors.
How do you know if you have a complex migraine headache? start experiencing pain in a specific area on one side of the head. Later on, the pain spreads and builds in intensity for going out of your head, and then gradually subsides. However, migraine headache can last up to 24 hours long, and in some cases, even for several days.